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Cucurbiturils
Biaxially ductile supramolecular polymer networks
Squeezable and 2D-stretchy ‘Super-jelly’:Supramolecular polymer networks are endowed with both enhanced compressibility and biaxial stretchability.
Sci. Adv.
(2026)
Tong Wu
,
Zixiang Zhou
,
Junting Huang
,
Zifan Wang
,
Du Wang
,
Jingzhou Wang
,
Zhengkai Han
,
Bohang Wu
,
Xinling Wang
,
Chengyu Zeng
,
Hui Li
,
Dan Xing
,
Jianhao Lin
,
Shaobo Ji
,
Yang Jiao
,
Ying Jiang
,
Yizheng Tan
,
You Zhou
,
Rui Shi
,
Zehuan Huang
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DOI
Stiffness Reinforcement in Polymer Networks Through Supramolecular Topological Linking
Supramolecular topological linking enables polymer networks that are simultaneously stiff and ductile, displaying exceptional stiffness scaling behavior.
Angew. Chem. Int. Ed.
(2026)
Bohang Wu
,
Junting Huang
,
Chengyu Zeng
,
Mingxin Zhong
,
Qin Ding
,
Du Wang
,
Jingzhou Wang
,
Zixiang Zhou
,
Tong Wu
,
Xinling Wang
,
Hui Li
,
Dan Xing
,
Jianhao Lin
,
Yiheng Wu
,
Yuwei Gu
,
Shixian Lv
,
Yuchong Yang
,
Yang Jiao
,
Guanglu Wu
,
Jasper van der Gucht
,
Martien A. Cohen Stuart
,
Tongfan Hao
,
Zehuan Huang
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DOI
How many fluorophores are required to achieve AIE?
Two is enough:An archetypal AIE fluorophore together with cucurbit[n]uril macrocyclic hosts enables the controlled formation of discrete dimers, shedding light onto the early stages of aggregation.
Chem. Sci.
(2025)
Tangxin Xiao
,
Zehuan Huang
,
Liangliang Zhang
,
Shuang Jin
,
Xiaoyi Chen
,
Hongwei Qian
,
Guanglu Wu
,
JadeA. McCune
,
Oren A. Scherman
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DOI
Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks
pH-driven kinetic locking: designed guest molecules modulate ion-dipole interactions with the hosts, resulting in mechanical switch of dynamicity within polymer networks.
J. Am. Chem. Soc.
(2025)
Stephen J.K. O’Neill
,
Yuen Cheong Tse
,
Zehuan Huang
,
Xiaoyi Chen
,
Jade A. McCune
,
Oren A. Scherman
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DOI
Biomimetic entropy-dominant molecular hinges with picomolar affinity
Supramolecular ‘retinal-opsin’: host-induced entropy-dominant molecular hinges with ultrahigh binding affinity are devised to mirror the natural retinal-opsin cycle.
J. Am. Chem. Soc.
(2024)
Zehuan Huang
,
Alexander S. Groombridge
,
Guanglu Wu
,
Magdalena Olesinska
,
Xiaoyi Chen
,
Jade A. McCune
,
Oren A. Scherman
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DOI
Highly stretchable dynamic hydrogels for soft multilayer electronics
Stretchable power source:supramolecular poly (ionic) networks with excellent mechanical properties and conductivity enable the soft multi-layer hydrogel devices for integrated bioelectronic platforms.
Sci. Adv.
(2024)
Stephen J. K. O'Neill
,
Zehuan Huang
,
Xiaoyi Chen
,
Renata L.Sala
,
Jade A. McCune
,
George G. Malliaras
,
Oren A. Scherman
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DOI
Tissue-mimetic supramolecular polymer networks for bioelectronics
Stand-alone bioelectrode: achieving tissue-like mechanical properties within conducting supramolecular networks enables fabrication of metal-free, intrinsically-stretchable bioelectrodes.
Adv. Mater.
(2023)
Stephen J. K. O'Neill
,
Zehuan Huang
,
Mohammed H. Ahmed
,
Alexander J. Boys
,
Santiago Velasco-Bosom
,
Jiaxuan Li
,
Róisín M. Owens
,
Jade A. McCune
,
George G. Malliaras
,
Oren A. Scherman
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Video
DOI
Highly compressible glass-like supramolecular polymer networks
Slow means strong: retarding crosslink dissociation kinetics within supramolecular networks enables fabrication of glass-like soft materials with ultra-compressibility.
Nat. Mater.
(2022)
Zehuan Huang
,
Xiaoyi Chen
,
Stephen J. K. O'Neill
,
Guanglu Wu
,
Daniel J. Whitaker
,
Jiaxuan Li
,
Jade A. McCune
,
Oren A. Scherman
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Video
DOI
On-resin recognition of aromatic oligopeptides and proteins through host-enhanced heterodimerization
Dimerize two different peptides within a host: quantitative heteropeptide dimers are utilized for the separation and stabilization of peptides and proteins.
J. Am. Chem. Soc.
(2022)
Xiaoyi Chen
,
Zehuan Huang
,
Renata L. Sala
,
Alan M. McLean
,
Guanglu Wu
,
Kamil Sokołowski
,
Katie King
,
Jade A. McCune
,
Oren A. Scherman
Preprint
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DOI
Host-enhanced phenyl-perfluorophenyl polar−π interactions
Find strength in weakness: a macrocyclic host is used to strengthen weak molecular interactions, thus providing a powerful driving force for the fabrication of functional materials.
J. Am. Chem. Soc.
(2020)
Zehuan Huang
,
Xiaoyi Chen
,
Guanglu Wu
,
Pierangelo Metrangolo
,
Daniel J. Whitaker
,
Jade A. McCune
,
Oren A. Scherman
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DOI
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